GMP Amoxicillin and Clavulanate Potassium Powder For Oral Medicine Grade
1. Product Name: Powder For Oral Made in China Amoxicillin and Clavulanate Potassium
2. Component: This product is a compound preparation, the following components: amoxicillin and clavulanic acid 400 mg / 5 ml 57 mg / 5 ml
3. Appearance: This product is a kind of white powder.Can add water mixture mixed suspension for oral, sugar-free, strawberry flavor.
4. Indications: Indications for this product is mainly used for suspected by producing beta lactamase amoxicillin resistant bacteria cause infection caused by short-term treatment, other cases should be considered a separate use of amoxicillin.
5. Specifications: Dry Suepension/ 2g:321.5mg
6. Usage and Dosage:
Mild and moderate infection (upper respiratory tract infection, such as: recurrent tonsillitis.Lower respiratory tract infection and skin soft tissue infection) : 28.6 mg per kilogram of body weight every day (25 mg, amoxicillin clavulanic acid 3.6 mg).
Mmore serious infection (upper respiratory tract infection, such as otitis media and sinusitis;Lower respiratory tract infections, such as: bronchial pneumonia;Urinary tract infection) : 51.4 mg per kilogram of body weight every day (45 mg, amoxicillin clavulanic acid 6.4 mg).
7. Contraindications: Always appeared on beta lactam antibiotics such as penicillin and cephalosporin allergy patients disabled this product.Always appeared jaundice or liver disorder associated with this product to disable this product.
8. Pharmacological mechanisms: This product is 457 mg / 5 ml dry suspension agent of amoxicillin and clavulanic acid can completely dissolved in water, under physiological pH and oral absorption is rapid, dine at the beginning of the best drug absorption.
On children's oral this product 3 times and 2 times/day/day of pharmacokinetic studies have found that renal function fully developed drug clearance kinetics of children the same as the adult.
Compare adult oral 875 mg / 125 mg tablet (2 times a day) or the product of 500 mg / 125 mg tablet (three times a day), with different doses of amoxicillin normalized processing, the results show that the average amoxicillin medication in the area under the curve (AUC) in the basic same, half-life and blood drug concentration.Also, with different doses of clavulanic acid normalized processing, compare the average clavulanic acid medicine area under curve (AUC), half-life and blood peak concentration also basically the same.
9. Storage: Below 25 ℃, dry place, seal preservation.
This product once made good, should be placed in the refrigerator cold storage (2 ~ 8 ℃), make a good finish this product must be taken at 7 days, if there are any remaining left, please.